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Proprietary complex of vitamins, minerals, and nutrients to assist the formation and function of healthy joint tissue. Ingredients such as MSM, help support the body’s response to everyday joint stress as well as, Glucosamine to support the building and prevent the breakdown of cartilage and fluid that naturally cushions the joints.*

DIRECTIONS:  Apply 1 patch to an area above the heart with little or no hair - shoulder, back or chest.  Avoid using any lotion or cream in the same area as it may inhibit the patches ability to stay adhered. Patch is not waterproof. 



Vitamin C (as mineral ascorbate): Vitamin C  is a powerful antioxidant that plays essential roles in joint health and immune function that may benefit people with arthritis. Vitamin C serves a role as a co-factor in collagen synthesis, the main protein in joint tissue and bone. Vitamin C plays a role in fighting infection and may work to control inflammation linked to infection, which may trigger arthritis flares.

Vitamin D3 (as cholecalciferol):  Vitamin D helps your bones absorb calcium, which is vital to bone health. It’s also crucial for muscle movement, communication between nerves, and fighting inflammation. According to the Arthritis Foundation, people who take oral steroids have a vitamin D deficiency twice as often as people who don’t take them. Another study  found that vitamin D deficiency is common in people with rheumatoid arthritis (RA), and may be linked to musculoskeletal pain.                                                     

Vitamin K2 (as menaquinone-7): Recent studies confirm that calcium plays an important role in the onset and development of symptoms of osteoarthritis because it uncontrolled deposition in the articular cartilage. This occurs in the absence of vitamin K2 when the organism is not able to properly utilize calcium, but it wanders on the body.

A large-scale study published in 2018 in the American Journal of Medicine, confirmed that nearly 60 percent more risk of osteoarthritis occurred in people who lack vitamin K.

Additionally, the study also showed that in 15 percent of patients who initially did not have any symptoms and lacked vitamin K, there was a development of osteoarthritis after 30 months of study duration. In conclusion, the research group highlighted the potential of vitamin K as a simple and acceptable treatment for osteoarthritis.

Magnesium (as magnesium citrate): Magnesium is a type of mineral and nutrient that is vital for the body to have for many reasons. It helps to provide protein to the bones, keep nerves functioning correctly, and ensure blood pressure stays at a healthy level. This mineral is able to help arthritis in many ways. Magnesium will fill your bones with vital nutrients which works to keep them strong. It helps with the metabolism of calcium which can boost bone health significantly. It can help to prevent bone fractures as well as keeping your arthritis from eventually becoming worse. In fact, a study published by scientific journal PLOS One showed that by using magnesium to keep bones strong, it could actually help to prevent osteoarthritis.

Zinc (as zinc L-monomethionine): Many think ligaments and tendons are the only tissue types that fall within the connective tissue category, but bone and cartilage are, too. In fact, it’s the mineralization of bone that makes our skeletons strong and the cartilage that makes our joints be able to move smoothly. Collagen makes up nearly all of the matrix proteins and numerous parts of a joint, including tendons, ligaments, and cartilage. When it comes to bone growth, zinc helps with the bone-building cells of the body (called osteoblasts) do their job as well as counteracting bone resorption.  You can think of resorption as the opposite of absorption; instead of your bones absorbing zinc resorption is when minerals leave your bones and go back into your bloodstream.  While a natural part in the cycle of bone health, too much resorption can cause problems such as decreased bone density.

Hydrolyzed Marine Collagen Type I & III: Collagen, considered the building blocks of the metabolism, is the second most plentiful substance in the body (after water). It is needed for the growth and repair of every cell in the body. Up to 40% of the body is made up of connective tissue with 70% of the connective tissue being collagen. Collagen is the protein that forms connective fibers in tissues such as skin, ligaments, cartilage and bones. Collagen acts as a kind of intracellular glue that gives support, shape and bulk to blood vessels, bones, and organs including the heart, kidneys and liver. 

Glucosamine Sulfate 2KCl: Glucosamine sulfate is a chemical found in the human body. It is used by the body to produce a variety of other chemicals that are involved in building tendons, ligaments, cartilage, and the thick fluid that surrounds joints. Joints are cushioned by the fluid and cartilage that surround them. In some people with osteoarthritis, the cartilage breaks down and becomes thin. This results in more joint friction, pain, and stiffness. Researchers think that taking glucosamine supplements may either increase the cartilage and fluid surrounding joints or help prevent breakdown of these substances, or maybe both. Some researchers think the "sulfate" part of glucosamine sulfate is also important. Sulfate is needed by the body to produce cartilage. This is one reason why researchers believe that glucosamine sulfate might work better than other forms of glucosamine such as glucosamine hydrochloride or N-acetyl glucosamine. These other forms do not contain sulfate.

MSM (methylsulfonylmethane): Methylsulfonylmethane, more commonly known as MSM, is a popular dietary supplement used to treat a wide array of symptoms and conditions. It’s a sulfur-containing compound found naturally in plants, animals and humans. MSM is widely used in the alternative medicine field and by people looking for a natural way to relieve joint pain, reduce inflammation and boost immunity. It has been shown to benefit those with joint degeneration, a common cause of pain in the knees, back, hands and hips. Studies have shown that MSM significantly reduces inflammation in your body. It also inhibits the breakdown of cartilage, a flexible tissue that protects the ends of your bones in joints

Ginger Root Extract (Zingiber officinale): Ginger root may help treat symptoms associated with osteoarthritis (OA) and rheumatoid arthritis (RA). Research shows that phytochemicals in ginger including gingerol, shogoal, and zingerone have anti-inflammatory properties that may help relieve arthritis joint pain and inflammation. In fact, lab studies show that these compounds inhibit several of the very same targets as arthritis medications. Anti-inflammatory phytochemicals in ginger can relieve pain and swelling associated with OA. A three-month clinical trial involving 120 people with knee osteoarthritis found ginger supplements help to decrease pro-inflammatory cytokines tumor necrosis factor (TNF) and interleukin-1-beta (IL-1b).       

Green-Lipped Mussel Extract (Perna canaliculus): Green-lipped mussel is a nutritional supplement taken from a type of mussel native to New Zealand. It contains omega-3 fatty acids, which have anti-inflammatory and joint-protecting properties. Evidence suggests that it might be of some use to people with osteoarthritis. Besides omega-3 fatty acids, it contains multiple amino acids and minerals. Laboratory and animal studies have shown omega-3 fatty acids have anti-inflammatory properties and are important for maintaining joint cell structure and function.    

White Willow Bark Extract (Salix alba): White willow trees grow a bark that contains the chemical called salicin, which has anti-inflammatory effects. Salicin works in similar ways as acetylsalicylic acid, the active ingredient in aspirin. In fact, in the 1800s, salicin was used to develop aspirin. Antioxidant compounds called polyphenolic glycosides and flavonoids are also found in white willow bark. These have been shown to protect against oxidative stress and various symptoms tied to aging, such as poor physical performance, cognitive decline, etc. Some research has demonstrated that white willow bark can help people dealing with chronic joint pain and injuries. Certain studies have shown that it can reduce osteoarthritis pain and back pain as well as certain prescriptions.

Bromelain (2400 GDU/g): Bromelain is a protein-digesting enzyme mixture derived from the stem, fruit, and juice of the pineapple plant. It has a centuries-long history of being used to treat medical ailments, primarily throughout Central and South America. A review of clinical studies found that bromelain’s anti-inflammatory and analgesic properties make it an effective treatment for the pain, soft-tissue swelling, and joint stiffness associated with osteoarthritis. The review focused on bromelain’s effectiveness in treating arthritis of the knee and shoulder. The studies analyzed varied significantly in terms of dosage. Improvements were found in some study participants given 400 milligrams of bromelain, two times daily.

AprèsFlex® Indian Frankincense Extract (Boswellia serrata): AprèsFlex is a novel synergistic composition derived from Boswellia serrata gum resin. A 30-day, double-blind, randomized, placebo-controlled study was conducted to validate the efficacy of AprèsFlex in the management of clinical symptoms of osteoarthritis (OA) of the knee. The study suggests that AprèsFlex conferred clinically and statistically significant improvements in pain scores and physical function scores in OA subjects. AprèsFlex provided significant improvements in pain score and functional ability in as early as 5 days of treatment.

*These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure or prevent any disease.

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